Researchers used ATAC-seq analysis to identify 16 distinct epigenomic subtypes of acute myeloid leukaemia, revealing how non-genetic mechanisms drive disease progression and drug response. This classification framework could enable personalised treatment strategies and improve outcomes for AML patients.
Nature.com · Wednesday, 8 July 2026
An ATAC-seq-based approach is used to classify acute myeloid leukaemia (AML) into 16 epigenomic subgroups, and provides insight into the role of non-genetic mechanisms in determining pathogenesis, clinical behaviour and drug sensitivity in this disease.
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