Researchers have identified manikomycin, a natural antibiotic with an entirely new molecular structure and mechanism of action, targeting a previously unexploited site on bacterial ribosomes. The discovery demonstrates a promising new approach to combating antibiotic-resistant infections through improved screening methods for natural compounds.
Nature.com · Wednesday, 3 June 2026
Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of the bacterial large ribosomal subunit.
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Read the full article at Nature.comTennessee has passed legislation requiring data centers to cover their own electrical infrastructure costs, preventing utilities from passing these expenses to residential customers. The bipartisan measure addresses growing concerns about grid strain and cost burden as data center demand surges across the state.
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